CONVENTIONAL THERAPIES DEPLETE BRAIN-INFILTRATING ADAPTIVE IMMUNE CELLS IN A MOUSE MODEL OF GROUP 3 MEDULLOBLASTOMA IMPLICATING MYELOID CELLS AS FAVORABLE IMMUNOTHERAPY TARGETS

Medulloblastoma is the most common childhood brain cancer.Mainstay treatments of radiation and chemotherapy have not changed in decades and new treatment approaches are crucial for the improvement of clinical outcomes.To date, immunotherapies for medulloblastoma have been unsuccessful, and studies investigating the immune microenvironment of the di

OBJECTIVES/GOALS: Uterine fibroids (UF), non-cancerous myometrial neoplasms, affect 11 million women in the US.In qualitative research, experiences of Black women (BW) and Latinas (HL) with UF are understudied.UF etiology is poorly understood, and most symptoms are focused on decreasing UF symptoms.This study will showcase a translational approach

Terrestrialization, the evolution of non-aquatic oviposition, and miniaturization, the evolution of tiny adult body size, are recurring trends in amphibian evolution, but the relationships among the traits that characterize these phenomena are not well understood.Furthermore, these traits have been identified as possible "key innovations" that are

The recognition of emotions and feelings through computer technology and devices has been widely explored in recent years.Social networks have become a natural environment in which users express their feelings and opinions through social media, and this includes their Facebook reactions.The aim of this study was to investigate whether the emoticons

Astrophysical point-like neutrino sources, like Gamma-Ray Bursts (GRBs), are one of the main targets for neutrino telescopes, since they are among the best candidates for Ultra-High-Energy Cosmic Ray (UHECR) acceleration.From the interaction mexican tamarind candy spoon between the accelerated protons and the intense radiation fields of the source